Pier Cirillo博士.D.

Pier Cirillo博士.D. Image
化学副教授
化学本科项目主任

Chemistry & 化学工程系
Tagliatela工程学院
Education

Ph.D. in Synthetic Organic Chemistry, 波士顿大学，1995年

B.Sc. Hons. in Chemistry, University of the Witwatersrand, 1987

博士论文

Chiral Allylic Silanes in Organic Synthesis: Formal Synthesis of (+)-Sesbanimide A. 哲学博士. 波士顿大学，1995年

研究兴趣

Before joining the faculty at the 网赌上分平台, I spent twelve years in medicinal chemistry research at a pharmaceutical company, designing and synthesizing kinase inhibitors and receptor modulators that have the potential to treat inflammatory diseases. My current research interest is the laboratory synthesis of: natural products and their analogs, polyoxygenated化合物, 杂环化合物. 动机是去发现, 与生物化学家合作, new compounds of potential medicinal interest such as antibiotics and anti-cancer chemotherapeutic agents. Special consideration is given to new, efficient, and green methods of synthesis.

学术出版物精选

Bartolozzi,.; Cirillo, P.F.; Berry, A.K.; Hickey, E.R.; Thomson, D.S.; Wu, L.; Zindell, R.; Albrecht, C.; Ceci, A.; Gemkow, M.J.; Nagaraja, N.V.; Romig, H.; Sauer, A.; Riether, D. 选择性CB2受体激动剂, Part 3: The Optimization of a Piperidine-Based Series that Demonstrated Efficacy in an In Vivo Neuropathic Pain Model. Bioorg. Med. Chem. Lett. 201525(3): 587-592.

Hickey, E.R.; Zindell R.; Cirillo, P.F.; Wu, L.; Ermann, M.; Berry, A.K.; Thomson, D.S.; Albrecht, C.; Gemkow, M.J.; Riether, D. 选择性CB2受体激动剂, Part 1: The Identification of Novel Ligands Through Computer Aided Drug Design (CADD) Approaches. Bioorg. Med. Chem. Lett. 201525(3): 575-580.

Lee, Y.; Mootien, S.; Shoen, C.; Destefano, M.; Cirillo, P.; Asojo, O.A.; Yeung, K.R.; Ledizet, M.; Cynamon, M.H.; Aristoff, P.A.; Koski, R.A.; Kaplan, P.A.; Anthony, K.G. Inhibition of Mycobacterial Alanine Racemase Activity and Growth by Thiadiazolidinones. Biochem. Pharmacol. 201386(2):222-230.

Bai, F.; Asojo, O.A.; Ciustea, M.; Ledizet, M.; Cirillo, P.; Aristoff, P.A.; Leng, L.; Bucala, R.; Koski, R.A.安东尼，K.G. Chicago Sky Blue 6B, A Novel Allosteric Inhibitor for Macrophage Migration Inhibitory Factor. J. Biol. Chem.2012 287: 30653-30663.

Ciustea, M.; Mootien, S.; Rosato, A.E.; Perez, O.; Cirillo, P.; Yeung, K.R.; Ledizet, M.; Cynamon, M.H.; Aristoff, P.A.; Koski, R.A.; Kaplan, P.A.; Anthony, K.G. Thiazolidinones: A New Class of Alanine Racemase Inhibitors With Antimicrobial Activity Against Methicillin-Resistant Staphylococcus aureus. Biochem. Pharmacol.201283: 368-377.

Riether, D.; Wu, L.; Cirillo, P.F.; Berry, A.; Walker, E.R.; Ermann, M.; Noya-Marino, B.; Jenkins, J.E.; Albaugh, D.; Albrecht, C.; Fisher, M.; Gemkow, M.J.; Grbic, H.; Löbbe, S.; Möller, C.; O’Shea, K.; Sauer, A.; Shih D.-T.; Thomson, D.S. 1,4-Diazepane Compounds as Potent and Selective CB2 Agonists: Optimization of Metabolic Stability. Bioorg. Med. Chem. Lett. 201121(7): 2011-2016.

皮耶·F·西里洛.; Hickey, Eugene; Breitfelder, Steffen; Betageri, Raj; Fadra, Tazmeen; Gaenzler, Faith; Gilmore, Thomas; Goldberg, Daniel; Kamhi, Victor; Kirrane, Thomas; Kroe, Rachel R.; Madwed, Jeffrey; Moriak, Monica; Netherton, Matthew; Pargellis, Christopher A.; Patel, Usha; Qian, Kevin C.; Regan, John R.; Sharma, Rajiv; Sun, Sanxing; Swinamer, Alan; Torcellini, Carol; Takahashi, Hidenori; Tsang, Michele, Xiong, Zhaoming; Moss, Neil Discovery and Characterization of the N-Phenyl-N’-Naphthylurea Class of p38 MAP Kinase Inhibitors. Bioorg. Med. Chem. Lett.200919(9): 2386-2391.

Regan, John; Capolino, Alison; 皮耶·F·西里洛.; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Kroe, Rachel R.; Madwed, Jeffrey; Moriak, Monica; Nelson, Richard; Pargellis, Christopher A.; Swinamer, Alan; Torcellini, Carol; Tsang, Michele; Moss, Neil. Structure-Activity Relationships of the p38a MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea (BIRB 796). J. Med. Chem.200346(22): 4676-4686.

皮耶·F·西里洛.; Pargellis, Christopher; Regan, John. The non-diaryl heterocycle classes of p38 MAP kinase inhibitors. Curr. Top. Med. Chem.20022(9): 1021-1035.

Regan, John; Breitfelder, Steffen; Cirillo, Pier; Gilmore, Thomas; Graham, Anne G.; Hickey, Eugene; Klaus, Bernhard; Madwed, Jeffrey; Moriak, Monica; Moss, Neil; Pargellis, Chris; Pav, Sue; Proto, Alfred; Swinamer, Alan; Tong, Liang; Torcellini, Carol. Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate. J. Med. Chem. 200245(14): 2994-3008.

Pargellis, Christopher; Tong, Liang; Churchill, Laurie; 皮耶·F·西里洛.; Gilmore, Thomas; Graham, Anne G.; Grob, Peter M.; Hickey, Eugene R.; Moss, Neil; Pav, Susan; Regan, John. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. 自然结构. Biol.20029(4): 268-272.

皮耶·F·西里洛.; 塞缪尔·丹尼舍夫斯基. The glycal assembly method on solid supports: synthesis of oligosaccharides and glycoconjugates. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries2001 15-40. P.H. Seeberger Ed.威利，纽约.

塞缪尔·丹尼舍夫斯基.; Hu, Shuanghua; 皮耶·F·西里洛.; Eckhardt, Matthias; 彼得·H·西伯格. A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a natural peptide motif. Chemistry-A European Journal 19973(10): 1617-1628.

彼得·H·西伯格.; 皮耶·F·西里洛.; Hu, Shuanghua; Beebe, Xenia; Bilodeau, Mark T.; 塞缪尔·丹尼舍夫斯基. Synthesis of the pentasaccharide core structure of asparagine-linked glycoprotein oligosaccharides by the glycal assembly method. 对映体1996,4 (4):311-323.

Jain, Nareshkumar F.; 皮耶·F·西里洛.; Pelletier, Roberta; 詹姆斯•帕内克. Double stereodifferentiation in the Lewis acid promoted crotylation of (S)-2-alkoxypropanal with chiral b-alkyl (E)-crotylsilanes. Tet. Lett. 199536(48): 8727-30.

皮耶·F·西里洛.; 詹姆斯•帕内克. Studies directed toward the synthesis of (+)-sesbanimide A: construction of the AB-ring system (a formal total synthesis). J. Org. Chem.199459(11): 3055-63.

詹姆斯•帕内克.; 皮耶·F·西里洛. Acyclic diastereoselectivity in the Lewis acid promoted additions of chiral, b-methyl-substituted (E)-crotylsilanes with achiral aldehydes. J. Org. Chem. 199358(5): 999-1002.

皮耶·F·西里洛.; 詹姆斯•帕内克. Recent progress in the chemistry of acylsilanes. A review. Org. Prep. Proc. Intl.199224(5): 553-82.

皮耶·F·西里洛.; 詹姆斯•帕内克. Diastereoselectivity in nucleophilic addition reactions to (a,b-dialkoxyacyl) silanes: an operationally useful route to optically active 1,2,3-syn-triols. J. Org. Chem.1990 55(25): 6071-3.

詹姆斯•帕内克.; 皮耶·F·西里洛. p-Facial selectivity in catalytic osmylation reactions of chiral C1-oxygenated allylic silanes. J. Am. Chem. Soc.1990 112(12): 4873-8.

最近的专业活动

Medicinal Chemistry Consultant – L2 Diagnostics, since 2011

Senior Lecturer – The 网赌上分平台 - 2013-2016

Lecturer – The 网赌上分平台 - 2009-2013

Principal Scientist – Boehringer Ingelheim Pharmaceuticals, Inc. - 2003-2008

Senior Scientist – Boehringer Ingelheim Pharmaceuticals, Inc. - 1997-2002

Post-Doctoral Research Fellow – Memorial Sloan-Kettering Cancer Center - 1995-1996

专业的会员

美国化学会会员

课程
  • 化学4501高级有机化学
  • 化学4550 /6650药物化学
  • CHEM 3341合成方法
  • 化学2201/2203有机化学(含实验室
  • CHEM 2202/2204 Organic Chemistry II with Lab
  • 化学1115/1117普通化学I含实验室
  • CHEM 1105 Intro General and Organic Chemistry with Lab